New Step by Step Map For cees dekker

Rotary motion of DNA rotors on nanopores. Major row: raw video of the Cy5 channel of each and every rotor. Middle row: corresponding one-particle localization benefits of both finishes of your DNA rotors. The placement of the current frame is marked as orange and blue dots, and the trajectory of The ten frames prior to The existing frame is demonstrated as solid traces.

1996, initial mesoscopic cost density waves equipment; and very first electrical measurements on one metal nanocluster among nanoelectrodes

Multicolor imaging in the bacterial nucleoid and cell division proteins with blue, orange, and near-infrared fluorescent proteins

2007, to start with genuine-time detection of strand Trade in homologous recombination by RecA; discovery of the reduced persistence size of finishes of microtubules; and resolved the mechanism of biosensing with carbon nanotubes

2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and 1st ever review from the dynamics DNA supercoils and the invention of supercoil hopping

Experimental section diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,

‘Initially we looked at Organic systems using a Bodily perspective and acted on the basis in the instruments we realized. It took a number of years prior to we commenced Doing the job much more on the large Organic difficulties. I then began to call it nanobiology, a term that did not exist at time.

Nanopores characterize a sublime and functional Resource to evaluate solitary molecules. We investigation novel detection modes with reliable-condition nanopores and many ways to evaluate proteins with nanopores. Jobs encompass the subsequent:

2003, shown the initial biosensors produced out of a carbon nanotube; fixed the framework and mechanism of DNA restore proteins; and discovery of a brand new technique for fabricating good-point out nanopores for DNA translocation

Dekker began his research on solitary carbon nanotubes in 1993 when he create a new line ceesdekker.net of investigate to review electrical transportation by way of single natural and organic molecules among nanoelectrodes. In 1996 a breakthrough was realized with carbon nanotubes. This was realized inside a collaboration While using the group of Nobel laureate Richard Smalley. STM and nanolithography techniques had been utilized to exhibit that these nanotubes are quantum wires at The one-molecule degree, with outstanding Bodily properties.

Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with research from scientific tests of DNA loop extrusion and supercoiling to DNA translocation by means of nanopores. More just lately his study has centered on studying chromatin framework and cell division with micro organism on chip, whilst he is likewise trying to finally Construct artificial cells from the bottom up.

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2013, managed shaping of live bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations within the handedness of histone tetrasomes